Junichi Sadoshima Selected Research

glycogen synthase kinase 3 alpha

12/2008	Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.
11/2007	Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases.

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Junichi Sadoshima Research Topics

Disease

42	Cardiomegaly (Heart Hypertrophy) 01/2022 - 05/2002
34	Heart Failure 01/2021 - 08/2003
31	Hypertrophy 11/2022 - 09/2002
23	Ischemia 01/2020 - 11/2002
16	Cardiomyopathies (Cardiomyopathy) 01/2022 - 02/2004
11	Myocardial Infarction 01/2019 - 11/2006
10	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 03/2011
9	Myocardial Ischemia (Ischemic Heart Diseases) 05/2022 - 05/2006
9	Fibrosis (Cirrhosis) 01/2021 - 05/2007
9	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2019 - 05/2003
8	Neoplasms (Cancer) 01/2020 - 10/2010
8	Heart Diseases (Heart Disease) 01/2018 - 01/2011
7	Hypertension (High Blood Pressure) 11/2022 - 07/2008
7	Reperfusion Injury 01/2022 - 01/2011
6	Hypoxia (Hypoxemia) 05/2022 - 12/2007
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 08/2012
6	Inflammation (Inflammations) 01/2019 - 11/2015
5	Left Ventricular Dysfunction 11/2022 - 11/2007
5	Obesity 12/2021 - 03/2012
5	Diabetic Cardiomyopathies 07/2021 - 01/2019
5	Infarction (Infarctions) 01/2018 - 09/2010
4	Starvation 01/2020 - 12/2010
3	Insulin Resistance 12/2021 - 02/2005
3	Infections 03/2021 - 09/2005
3	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2018 - 06/2014
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2014 - 03/2012
3	Body Weight (Weight, Body) 08/2010 - 07/2002
2	Muscular Atrophy (Muscle Atrophy) 01/2019 - 07/2011
2	Proteostasis Deficiencies 10/2018 - 08/2017
2	Vascular Diseases (Vascular Disease) 02/2017 - 01/2011
2	Atherosclerosis 03/2016 - 01/2011
2	Atrial Fibrillation 12/2014 - 09/2009
2	Ventricular Remodeling 04/2013 - 11/2006
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 11/2009 - 10/2006
2	Bradycardia 02/2007 - 08/2003
1	Cicatrix (Scar) 11/2022

Drug/Important Bio-Agent (IBA)

27	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
14	Sirtuin 1IBA 01/2020 - 08/2006
13	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2021 - 11/2006
12	Phosphotransferases (Kinase)IBA 01/2019 - 11/2002
10	Beclin-1IBA 01/2022 - 03/2007
10	AntioxidantsIBA 12/2021 - 11/2003
9	NADPH Oxidases (NAD(P)H oxidase)IBA 05/2022 - 08/2010
9	Angiotensin IIIBA 01/2017 - 09/2006
8	Mechanistic Target of Rapamycin Complex 1IBA 01/2022 - 03/2012
8	ThioredoxinsIBA 07/2021 - 11/2003
8	Glycogen Synthase (Synthase I)IBA 01/2021 - 09/2002
8	Protein Isoforms (Isoforms)IBA 01/2019 - 11/2009
7	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2021 - 07/2003
6	Histone Deacetylases (Histone Deacetylase)IBA 01/2014 - 06/2008
6	Adrenergic Agents (Adrenergic Drugs)IBA 07/2011 - 07/2003
5	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 03/2007
5	Transcription Factors (Transcription Factor)IBA 01/2022 - 06/2007
5	NAD (NADH)IBA 01/2021 - 08/2006
5	beta Adrenergic ReceptorsIBA 02/2009 - 07/2003
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2022 - 04/2013
4	EnzymesIBA 12/2021 - 01/2014
4	Peptides (Polypeptides)IBA 04/2020 - 04/2008
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 11/2015
4	Protein Kinases (Protein Kinase)IBA 01/2019 - 06/2005
4	MicroRNAs (MicroRNA)IBA 10/2016 - 01/2011
4	Atrial Natriuretic Factor (ANF)IBA 08/2010 - 07/2002
4	Glycogen Synthase Kinase 3 betaIBA 12/2008 - 05/2002
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022 - 10/2018
3	Serine (L-Serine)FDA Link 01/2022 - 12/2008
3	Adenosine Triphosphate (ATP)IBA 01/2021 - 01/2015
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021 - 11/2008
3	LipidsIBA 01/2020 - 01/2019
3	Mitochondrial Proteins (Mitochondrial Protein)IBA 10/2019 - 04/2010
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019 - 07/2011
3	CytokinesIBA 01/2019 - 07/2002
3	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2018 - 05/2005
3	SaltsIBA 04/2017 - 01/2012
3	SirtuinsIBA 11/2015 - 08/2006
3	Sirolimus (Rapamycin)FDA Link 11/2014 - 08/2012
3	CalcineurinIBA 05/2014 - 09/2003
3	Cysteine (L-Cysteine)FDA Link 02/2013 - 08/2009
3	AMP-Activated Protein KinasesIBA 03/2011 - 03/2007
3	Caspase 3 (Caspase-3)IBA 08/2009 - 12/2007
3	Glycogen Synthase KinasesIBA 11/2007 - 05/2002
2	NADPH Oxidase 4IBA 12/2021 - 01/2020
2	CollagenIBA 01/2021 - 10/2016
2	Adenosine Triphosphatases (ATPase)IBA 01/2020 - 01/2018
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 04/2010
2	LigandsIBA 01/2019 - 11/2013
2	Dynamins (Dynamin)IBA 01/2019 - 04/2008
2	Galectin 3 (LGALS3)IBA 01/2019 - 01/2018
2	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2019 - 11/2014
2	SpermidineIBA 04/2017 - 12/2016
2	GTP-Binding Proteins (G-Protein)IBA 03/2014 - 08/2012
2	Glycogen Synthase Kinase 3IBA 08/2011 - 12/2008
2	Phosphatidylinositols (Phosphatidylinositol)IBA 09/2009 - 06/2005
2	glycogen synthase kinase 3 alphaIBA 12/2008 - 11/2007
2	DNA (Deoxyribonucleic Acid)IBA 04/2008 - 11/2002
2	p38 Mitogen-Activated Protein KinasesIBA 12/2007 - 02/2004
2	Insulin (Novolin)FDA Link 12/2007 - 02/2005
2	CaspasesIBA 06/2005 - 05/2003
2	Mitogen-Activated Protein KinasesIBA 02/2004 - 09/2002
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2022

Therapy/Procedure

7	Therapeutics 01/2019 - 02/2004